Trio of scientists win Nobel Prize for immune system regulation

Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the Nobel Prize in Physiology or Medicine 2025 for their groundbreaking discoveries in peripheral immune tolerance—how the immune system uses regulatory T cells to prevent other immune cells from attacking our own body. Their work laid the foundation for a new field of research and spurred the development of treatments for cancer and autoimmune diseases.