90% of cystic fibrosis patients soon can be treated

January 19, 2016 News BioVox

Galapagos and AbbVie aim to develop a promising therapy to address 90% of patients with CF (cystic fibrosis). It concerns a triple combination therapy. The companies plan to develop multiple candidates and backups for each of the three components (1st generation correctors, next generation correctors, and potentiators), with the goal of identifying a potential triple combination. In this way, they hope to bring a more effective therapy to patients.

Triple combinations of CF compounds in the portfolio have consistently shown restoration of healthy activity levels in in vitro assays with human bronchial epithelial (HBE) cells of patients with the F508del mutation. In addition to the potentiator and corrector that are being tested in the clinic, a total of four additional compounds have the potential to reach clinical development in the CF program this year.

“Galapagos and AbbVie continue to make strong progress with our cystic fibrosis portfolio,” says Onno van de Stolpe, CEO of Galapagos. “The CF franchise has really expanded into a full-sized portfolio. The resulting breadth, depth, and preclinical promise of this collection of modulators brings us again closer to our aim of bringing a superior triple combination therapy to CF patients.”


Avatar photo
BioVox

With a local focus and global reach, the news platform BioVox shares insights into the Benelux life sciences ecosystem with readers across the world. BioVox is an independent publisher, providing its community with quality content and first-row access to interesting breakthroughs and trends in biotech, medtech, agtech, pharma, and more. We shine a spotlight on the latest news and innovations from both our partners and community.

All posts

Subscribe to the BioVox newsletter