Immunology

Biomedical/pharma, Immunology, Oncology, Plant science

Antibodies have long held promise as a ‘magic bullet’ for cancer therapies, yet many antibody-drug conjugates face issues with toxicity and resistance. Belgian startup ATB Therapeutics is producing a new type of weaponized antibodies, using plants as mini factories for safe, effective cancer and autoimmune treatments.
VIB’s podcast Called to Science is back for a second season—a series where science journalist Brad Van Paridon sits with researchers to go beyond the science: exploring the passion, setbacks, and big questions that motivate them. In this episode, Bart Lambrecht—director of the VIB Center for Inflammation Research and a practicing physician at Ghent University Hospital—dives into the overlaps between treating patients, running a lab, and the fascination that drives him forward.
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the Nobel Prize in Physiology or Medicine 2025 for their groundbreaking discoveries in peripheral immune tolerance—how the immune system uses regulatory T cells to prevent other immune cells from attacking our own body. Their work laid the foundation for a new field of research and spurred the development of treatments for cancer and autoimmune diseases.
Buses full of innovators, lab doors wide open and conversations to spark collaboration—that was the vibe for BioWin on Tour on 24 September 2025, co-organized with AWEX. It was a whirlwind visit, with fifty international delegates from nine countries visiting two of Wallonia’s flagship science hubs—LégiaPark and BioPark Charleroi—discovering the region’s twin strengths of ATMPs and nuclear medicine.
In the space of just a few years, MRM Health has transformed from a challenger in the emerging microbiome therapeutics field to a global forerunner. CEO Sam Possemiers has steered the Belgian company through the rollercoaster of scientific uncertainty and investor skepticism to reach what he calls the “slope of enlightenment.” Now, with late-stage clinical trials ahead and a new important funding round within reach, Possemiers is sharing his lessons-learned with other biotech CEOs.
According to the World Health Organization (WHO) SARS-CoV-2 is experiencing a resurgence, with the risk of future outbreaks from emerging variants remaining substantial. To stay ahead of the curve, continued investment in both preventative measures and novel therapies is vital. Groundbreaking Belgian research is leading the way with high-potential compounds targeting SARS-CoV-2, offering a promising new avenue for treatment and pandemic preparedness.
Gluten-free dietary products contain more sugar and fats but fewer nutrients and are generally more expensive. A gluten-free diet can even lead to social isolation and stigmatization. Scientists are thus looking for a way that allows people with celiac gluten intolerance disease to enjoy the benefits of gluten in a safe manner.
Muna Therapeutics is developing transformative therapies for neurodegenerative diseases. These drugs aim to preserve cognition and enhance the brain’s resilience in diseases like Alzheimer’s and Parkinson’s, providing much-needed hope for millions of patients and their loved ones.
Agomab Therapeutics NV (‘Agomab’) today announced the closing of a $100 million (€94.9 million) Series C financing round led by Fidelity Management & Research Company, with participation from new investors EQT Life Sciences (EQT), Canaan, Dawn Biopharma, a platform controlled by KKR, and existing investors.
Coave Therapeutics is a French biotech developing gene therapies for neurodegenerative and ocular diseases. The company has developed a technology platform that can be used to redecorate the outer surface of viruses, creating gene therapy vectors that are better at accurately delivering healthy genes to the right target cells, including neurons in the deep brain tissue. By combining this vector technology with transgenes restoring natural cell cleaning pathways, the company has created a pipeline of therapies for both genetically and non-genetically defined neurodegenerative diseases, such as Parkinson’s Disease, Multiple System Atrophy (MSA), and Amyotrophic Lateral Sclerosis (ALS).
The COVID-19 pandemic has brought vaccines back into the drug development spotlight, and mRNA vaccines are stealing the show with sales of USD 54.4 billion in 2021 alone. Few know that the developers of the mRNA COVID-19 vaccines actually drew upon years of experience attempting to develop cancer vaccines. This approach goes back several decades, and although the field has to date seen limited success, it has nevertheless witnessed a renewed interests in recent years. We examine the latest trends in cancer vaccine development, and where the opportunities lie for the future of the industry.
The young Belgian start-up Persomed is unique – it was founded in 2020 by four partners each with relevant expertise in the personalized immunotherapy field: myNEO, QbD Group, Antleron, and the VUB. Together, the multidisciplinary strength and expertise has resulted in the development of Persomed’s cutting-edge technology platform for personalized cancer treatments. The organization is now at crucial point, raising funds to initiate a clinical trial phase I in a first, urgent-medical-need indication: metastatic colorectal cancer.
The microbiome has been a trending scientific topic in recent years. Researchers have uncovered correlations between the human microbiome and a wide range of diseases and health states, ranging from digestive issues to mental wellbeing. But no matter how fascinating these academic findings may be, translating them into concrete clinical applications remains a challenge. How can we enable more efficient clinical valorization of microbiome insights, and pave the way from pattern to patient?