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Liesbeth Demuyser

Life in plastic – not so fantastic

Researchers are sounding the alarm – there could be as much as a spoon’s worth of plastic inside our brain. Industrial activity, tire dust, lost fishing gear, and excessive use of disposable plastics are important drivers of microplastic pollution in our environment and, ultimately, in our bodies. While the full impact on human health is still being investigated, the fact that these particles can migrate into deeper tissues of our brain, crossing the blood-brain barrier, is worrying to say the least.

Belgian research pushes the boundaries of coronavirus treatment to prevent the next pandemic

According to the World Health Organization (WHO) SARS-CoV-2 is experiencing a resurgence, with the risk of future outbreaks from emerging variants remaining substantial. To stay ahead of the curve, continued investment in both preventative measures and novel therapies is vital. Groundbreaking Belgian research is leading the way with high-potential compounds targeting SARS-CoV-2, offering a promising new avenue for treatment and pandemic preparedness.

When ignorance isn’t bliss – more knowledge is crucial to combat deadly Candida auris fungus 

Infectious diseases are commonly associated with bacteria and viruses. However, fungi should also be added to this list as there is growing concern that antifungal resistance could be the next global challenge. Moreover, because fungi are eukaryotic like humans, developing targeted treatments without causing toxicity to the host presents a significant challenge. The World Health Organization has recently published its first list of health-threatening fungi. This list aims to promote research to enhance the global response to fungal infections and the growing issue of antifungal resistance. One ‘high-priority’ fungus in particular, Candida auris, has mycologists holding their breath due to its rapid global spread and multidrug resistance.

The race for biotech talent – innovate or fall behind 

Belgium has long been and remains a global leader in biotech and biopharma, for now at least. The question is: can it maintain that position? Talent and know-how have been key drivers of the country’s success, yet the system supplying both is under pressure. Job openings in the biotech and pharma sectors are growing faster than the educational system can keep up, creating a persistent talent shortage. However, it's not simply a matter of numbers. As the skills needed to support and advance local innovations evolve – AI integration being a prime example – how can we adapt our educational approach while ensuring its stability? This is a question that needs to be answered in order to stay at the forefront of innovation.

Aiming for Europe, but starting with the world – how restrictive EU legislation drives biotech innovation in agrifood abroad

Meeting the needs of a growing global population while addressing the clear demand for a more sustainable food supply is challenging but not impossible. Innovative biotechnological tools are constantly being created, and they are increasingly available on the market. However, the industry is in desperate need of support, as EU legislation can act as more of a hurdle than a facilitator, hindering local advancement. flanders.bio is committed to advocating for the sector and highlights the most pressing challenges in their latest policy paper.

Using patient data to enable personalized healthcare, ATHENA shows us how!

Personalized healthcare is characterized by tailoring treatments to each individual patient’s needs. Despite evident benefits, implementing such a system is not straightforward. The ATHENA project consortium has successfully devised a set of building blocks to address the challenges associated. Both technological and governance tools were developed that can now be used on a larger scale to catalyze the transition towards personalized medicine and care.

Navigating between patient privacy and healthcare innovation

The emergence of artificial intelligence and machine learning accelerates research and innovation across various sectors, particularly in healthcare. The potential for the development of innovative diagnostic tools and therapies based on insights from health data is limitless. However, progress should never compromise the privacy of patients. It’s a delicate balance that is essential to maintain.

From successful conception to a healthy family – Belgian research raises the bar for IVF

Belgium is one of the top countries in the world for in vitro fertilization (IVF). Despite the high cumulative success rates of these interventions, disproportionally little attention has been given to the health of both mother and child during and after pregnancy. With the HEART (High risk for pre-Eclampsia after Assisted Reproductive Technology) project, Belgian researchers strive to understand why some women have an increased risk for pre-eclampsia after IVF and whether biomarkers can be identified to estimate these risks early in pregnancy or even before conception. They aim to raise the standard from successful conception to improved child and maternal health.

This vagina-on-chip model holds the potential to advance yeast infection research

While a vast majority of women experience vaginal yeast infections, research has fallen short in providing an effective treatment approach. However, hope has emerged recently with the development of new model systems that allow exploration of the complex vaginal environment. Organ-on-chip models enable researchers to examine the interactions between human cells and microbes in a more accurate manner, offering the potential for the development of new therapies.

Optimizing the patient care pathway through data-driven insights

The patient’s journey in a healthcare setting is influenced by factors beyond the mere medical aspects of the case. Local variations in care procedures among hospitals and caregivers enable benchmarking and adaptation of practices to optimize outcomes. For effective process modeling, it’s essential to collect data and extract insights. To optimize this process efficiently, collaborative efforts should explore alternative data sources and implement novel tools.

Smart cities as living laboratories: a data-driven strategy for creating a sustainable future

Similar to the growing use of large-scale scientific data to guide laboratory research, urban data presents significant potential for informed decision-making in city governance. Extensive data on waste collection, traffic, pollution, and various other facets of city management can be collected and analyzed to help policymakers identify challenges and develop prediction-based solutions. Thomas Van Oppens, Deputy Mayor of Leuven, underscores the importance of local collaboration in establishing such a data-driven growth model for city governance.

Belgian breakthrough in endometriosis research captures investors’ attention

Even though endometriosis impacts millions of women globally, the condition remains poorly understood and researched, leading to delayed diagnosis and lack of effective treatment. Encouragingly, there are promising recent developments in the field coming from Belgium. Professor Hugo Vankelecom’s research group at KU Leuven uses advanced cellular models, known as organoids, to delve into the disease and expedite the drug discovery process. The Danish BioInnovation Institute now offers the team an incubation program to pave the way towards industrial success.

Using real-world data for post-market surveillance of drug safety

After a therapeutic drug hits the market, it is crucial to continuously gather, analyze, and report data regarding its safety and potential side effects, a practice known as pharmacovigilance. Unlike clinical trials, this involves real-world data (RWD), presenting unique challenges in terms of both quality and quantity. The Belgian BELpREG project seeks to employ RWD for monitoring drug utilization during pregnancy and investigating potential safety implications for both maternal and child health. This initiative holds great promise, although it faces substantial hurdles on its path to success.

Health data standardization: What FHIR can do for you!

Patient data is a treasure trove of information, vital to tailoring individual care pathways and generating profound insights to enhance healthcare more broadly. However, achieving interoperability among the diverse systems employed by various healthcare providers remains a critical challenge. Data standards like FHIR can help to streamline the secure exchange and seamless integration of healthcare data across these different systems. This article will take you through the FHIR framework and how it could be used by your organization.

Pharmaceutical market access: how real-world data fuel better health beyond clinical trials

Studies of a drug's effectiveness and safety don’t end with clinical trials – they extend beyond market access when the true value of a drug is demonstrated in a real-world setting. Based on this information, factors such as availability, pricing, and reimbursement are adjusted. To study the actual worth of a treatment, we require real-world data (RWD) from a large and diverse patient population. By actively sharing this information with stakeholders, we can fuel further research and innovation, and even help to inform decision-making on a population level. But in order to unlock the full potential of our patient data, all members of the ecosystem have to work together.