Infectious disease

Biomedical/pharma, Immunology, Infectious disease

Moderna Therapeutics has never really been a typical biotech. Sure, nowadays it is world famous thanks to its COVID-19 vaccine, which has resulted in an $80 billion market cap and projected sales of $18.4 billion for 2021. But the path to success has not been that of a standard biotech’s journey. Through ups and downs, controversies and triumphs, here’s the fascinating story behind the rise of Moderna and the creation of its COVID-19 vaccine.
Although the crisis has not yet passed, COVID-19 has already taught us many valuable lessons. This past year has tested us all, but governments and companies across the world have come together to tackle this global health challenge. In February, industry leaders from Flanders and Canada joined in a webinar, organized by Flanders Investment and Trade (FIT) and The Embassy of Canada to Belgium and Luxembourg, to discuss how we can already start applying our newfound knowledge to help prepare for the next pandemic.
Increased pollen concentrations are correlated with higher rates of COVID-19. Hot on the heels of record-breaking European pollen counts, this comes as bad news for a continent struggling with the ongoing health crisis. The large-scale study, conducted by an international team headed by researchers in Germany, suggested people protect themselves by keeping an eye on pollen forecasts and wearing particle filtering masks this spring.
Ghent, Belgium, 23 February 2021 - The Ghent company Biogazelle and the medical laboratory Labo Nuytinck (Ghent, Evergem), together with several Flemish companies, have developed a PCR platform with which thousands of saliva samples can be tested daily for the COVID-19 virus. The saliva test costs a third of a classic test.
One year on from the emergence of SARS-COV-2 in Wuhan, China, this novel coronavirus continues to devastate the world. Since then, COVID-19 has reached every continent and touched all of our lives. In this article, we take the chance to assess the situation going into 2021 and look back on the first year of the pandemic.
Niel, Belgium, 1 December 2020 - eTheRNA immunotherapies NV (“eTheRNA”) announced it has entered into a strategic cooperation and product license agreement with China Grand Pharmaceutical & Healthcare Holdings Ltd (“China Grand Pharma”) to establish a new joint venture company, Nanjing AuroRNA Biotech Co., Ltd. (“AuroRNA Biotech”) in Mainland China to deploy eTheRNA’s proprietary mRNA technology for pharmaceutical research and development and production in the Greater China Region.
Gent, Belgium, 27 October 2020 – Today V-Bio Ventures announces its investment in Animab, a new venture spin-off from VIB, in a EUR 3.4 million Seed financing round. The company develops monoclonal antibodies for oral administration to ensure intestinal health of livestock. The initial focus is on improving the resilience of piglets during the fragile post-weaning period. The start-up will use the seed capital to develop its first oral antibody product for protection against ETEC and initiate a product portfolio for the livestock industry.
For decades, researchers have been trying to uncover the cause of nodding syndrome, a mysterious and deadly form of epilepsy that only affects children on the African continent. In a collaboration between Belgian and African scientists, researchers from the University of Antwerp have now discovered the root cause of the disease. In a cascade of events, nodding syndrome is triggered by another disease called river blindness, which in turn is caused by parasitic worms spread by blackfly bites. As complicated as it sounds, this is great news for the children, as it means that nodding syndrome can easily be controlled by administering the anti-parasitic drug ivermectin and exterminating blackflies.
In July 2020, VIB spin-off ExeVir Bio raised €23 million to advance a llama-derived antibody against COVID-19. The company is based on the work of VIB researchers, who showed that these nanobodies can protect against the coronavirus in lab animals. ExeVir has now announced it will start testing the drug in COVID-19 patients in the coming months. The scientists are aiming to have the therapy ready for widespread use by spring 2021.
Many of our current antiviral, antibacterial and anti-tumour medications are comprised of combinations of two or three active substances, selected on the basis that these combinations slow down emergence of drug resistance. We are currently witnessing a rapid expansion of disease indications for which exploratory drug combos are being tested, as well as of the rationales for combining drugs. In this article, we examine the drivers behind this trend and the inherent caveats and complexities of drug combo development.
Ghent, Belgium, 28 July 2020 – Today V-Bio Ventures announces its investment in a EUR 23 million Series A financing into ExeVir Bio. The round was led by Fund+, with the participation, next to V-Bio Ventures, of VIB, UCB Ventures, SFPI-FPIM, and several Belgian family offices. ExeVir Bio has been established by Belgian partners combining world class science, antibody engineering, manufacturing, blue-chip venture capital investment and Flemish Government financing, which have joined forces in a unique collaboration to boost the development of new therapies to combat Covid-19.
With COVID-19 cases soaring into the millions, and a vaccine still a long way off, patients are desperate for a treatment. In response, numerous clinical trials have been initiated around the world. The majority of these trials are examining existing drugs to see if they can be repurposed to treat COVID-19. We spoke with Prof. Bart Lambrecht, pulmonologist at Ghent University Hospital (UZ Gent), about some of the clinical trials taking place here in Belgium.
Ghent, Belgium, April 2, 2020 - Biogazelle NV, a CRO specialized in RNA analytics, has announced the initiation of large-scale testing of patient samples for SARS-CoV-2. Biogazelle is providing one of the multiple testing sites in a government-led consortium of pharma, biotech, IT and academia, alongside Janssen Pharmaceutica (J&J), GSK, UCB, UgenTec, MIPS and ThermoFisher.