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Discovery and research

Prestigious prize for Belgian breakthrough in brain research

Prof. Dr. Pierre Vanderhaeghen from VIB-KU Leuven has been awarded the Generet Prize for Rare Diseases for his research on human brain development. Vanderhaegen’s team have developed an astonishing model for studying rare neurological disorders by successfully integrating human neurons into a mouse brain. The prestigious prize, managed by the King Baudouin Foundation and presented to Vanderhaeghen by HRH Princess Astrid, includes EUR 1 million in funding for further studies.

Decades-old discoveries cause paradigm shifts in modern medicine

Complete paradigm shifts in medicine are rare, but there have nevertheless been several major examples in the past hundred years. Treatments and approaches that seemed set in stone one decade can easily seem silly the next, as new information about the disease or underlying biology comes to light. Hindsight grants us clarity, but sometimes the factors that lead us down a particular treatment path can be as arbitrary as a feud between colleagues. Might there be paradigm shifts looming in oncology, neurology and more, triggered by a return to previous treatments?

The rapid evolution of Chinese biotech

The world is smaller today than it has ever been. With the COVID-19 pandemic, we have seen the advantages of a connected international pharma and biotech industry, which was able to rapidly mobilize to provide solutions for this global threat. The pandemic is not the only opportunity for cross-border collaborations, however. With an increasing focus on healthcare innovation, the rapid evolution of Chinese biotech is bringing benefits to companies and patients around the world.

Get to know Lewis Cantley: winner of the 2020 Dr. Paul Janssen Award

Every year, the Dr. Paul Janssen Award for Biomedical Research is granted to a scientist who embodies the eponymous man’s dedication to his patients and unfailing curiosity and passion for scientific progress. The 2020 winner of this prestigious award is Dr. Lewis Cantley, who discovered the family of PI3K enzymes, thereby increasing our understanding of a wide range of diseases including cancer and diabetes. Nearly 30 years on from this seminal discovery, Dr. Cantley’s research has resulted in more precise cancer therapies that have saved patient lives, making him a true champion of science.

UAntwerp researchers find cause for mysterious nodding syndrome

For decades, researchers have been trying to uncover the cause of nodding syndrome, a mysterious and deadly form of epilepsy that only affects children on the African continent. In a collaboration between Belgian and African scientists, researchers from the University of Antwerp have now discovered the root cause of the disease. In a cascade of events, nodding syndrome is triggered by another disease called river blindness, which in turn is caused by parasitic worms spread by blackfly bites. As complicated as it sounds, this is great news for the children, as it means that nodding syndrome can easily be controlled by administering the anti-parasitic drug ivermectin and exterminating blackflies.

Can Darwin’s theory explain why we get sick?

While physicians care for their individual patients and are interested in the factors contributing to the individual’s condition, evolutionary biologists investigate the cause of the biological phenomenon, trying to understand for example why a certain disease has developed in a particular species such as our own Homo sapiens. By combining the view of physicians with the view of evolutionary biologists, the field of evolutionary medicine has the potential to improve our understanding of certain diseases and how to prevent them.

Lewis Cantley awarded Dr. Paul Janssen Award for Biomedical Research 2020

Johnson & Johnson Celebrates Role of Scientists In Society with 2020 Dr. Paul Janssen Award for Biomedical Research, Part of the Champions of Science® Initiative - Lewis Cantley, Ph.D. Named 2020 Award Winner for the Discovery of PI3K Enzyme and its Role in Wide Range of Diseases from Diabetes to Cancer

VIB: the driving force behind a booming biotech ecosystem

Since VIB was established, the world class research institute has been led by a duo of managing directors. As Johan Cardoen recently stepped down for health reasons, Jérôme Van Biervliet has been chosen for the position alongside Jo Bury. We sat down with both Jérôme Van Biervliet and Jo Bury to hear their thoughts on VIB’s vital role in the ever-evolving Belgian biotech ecosystem.

Colorectal cancer discovery raises hope for microbiome treatment

A new mechanism causing colorectal cancer has been discovered by researchers from VIB and Ghent University. A specific protein was found to affect the integrity of the intestinal wall, allowing infiltrating bacteria to cause inflammation that drives cancer progression. Promisingly, the scientists also demonstrated that manipulating the immune system or microbiome can prevent this chain event, findings that may lead to new treatments for colorectal cancer.

Fundamental research leads to treatment breakthrough in rare genetic diseases

A basic research breakthrough is improving patient lives, as researchers realized their rare genetic condition could be treated by repurposing a common anti-diabetic medication. The treatment has already been tested on several patients and has been a huge success with clinical trials now being initiated around the world.

Talking T cells with David Masopust

Immunology is a complex but vitally important branch of the life sciences. Earlier this year, we attended a Keystone Symposia conference on T cell immunology as media partners. There, we got to speak with Prof. David Masopust, the man who discovered resident memory T cells. His seminal breakthrough opened up a new branch of T cell biology and catapulted the field forwards. Masopust shares his thoughts on the enormous untapped potential of T cells in new treatments and vaccines.

Belgian clinical trials for COVID-19

With COVID-19 cases soaring into the millions, and a vaccine still a long way off, patients are desperate for a treatment. In response, numerous clinical trials have been initiated around the world. The majority of these trials are examining existing drugs to see if they can be repurposed to treat COVID-19. We spoke with Prof. Bart Lambrecht, pulmonologist at Ghent University Hospital (UZ Gent), about some of the clinical trials taking place here in Belgium.

University Hospital Ghent and VIB are testing medication to treat COVID-19-associated respiratory illness

University Hospital Ghent and VIB are assessing a drug called Leukine® to treat patients with respiratory illness associated with COVID-19.  Major medical centers in Germany and Italy are considering joining the study.  The study will evaluate the effect of Leukine® on lung function and patient outcomes.

Professors of Product Development from UAntwerp are looking at emergency production of mouth masks

At the University of Antwerp, twelve product developers are working day and night to develop oral masks. "Together with industrial partners, we try to set up an emergency production for protective equipment for health workers during this corona crisis".

The long-distance race for a corona vaccine

Developing a vaccine takes a long time and occurs in different phases. A virus spreads quickly and unpredictably. Therefore, the outcome is a gamble for anyone in the race for the corona vaccine.