Heart failure is a serious disease with a prevalence of more than 60 million patients globally and still growing. Corteria’s innovative approach consists of selecting therapeutic targets involved in the worsening and acute forms of human heart failure, as well as a stratification strategy to identify specific subgroups that are most likely to benefit from the treatments. These forms of heart failure are widespread, life-threatening, and not directly addressed by the current standards of care.
Corteria was founded in 2021 by Sanofi’s former head of cardiovascular research, Philip Janiak, and Marie-Laure Ozoux, former cardiovascular project leader at Sanofi, around two cardiovascular programs in-licensed from Sanofi[1].
Since then, Corteria’s pipeline has expanded rapidly and today comprises three first-in-class therapies that are highly differentiated as they produce multi-organ benefits, acting on the kidneys, the vessels, and the heart:
- A once-daily subcutaneous CRF2[2] agonist for the treatment of Worsening Heart Failure
- A once-monthly subcutaneous CRF2[2] agonist for the treatment of Right Heart Failure
- An AVP (arginine vasopressin) neutralizing monoclonal antibody for the treatment of Acute Heart Failure with Hyponatremia
The lead asset for Worsening Heart Failure is expected to enter the clinic in early 2024.
[1] CRF2 peptide agonist and AVP neutralizing monoclonal antibody programs
[2] Corticotropin-releasing hormone receptor 2
About V-Bio Ventures
V-Bio Ventures is an independent venture capital firm specialized in building and financing young, innovative life sciences companies. V-Bio Ventures was established in 2015 and works closely with Belgium-based VIB, one of the world’s premier life science institutes. The fund invests throughout Europe in start-up and early-stage companies with high growth potential focusing on technologies that provide transformational improvements in the biopharmaceutical, pharmaceutical, diagnostics and agricultural sectors.
About Corteria Pharmaceuticals
Founded in 2021, Corteria Pharmaceuticals is a privately held biopharmaceutical company developing first-in-class drugs in heart failure subpopulations. Despite some improvements in the management of this serious disease, the prevalence of heart failure keeps increasing with more than 60 million patients worldwide. Corteria’s strategy implies innovative patient stratification and target selection based on human evidence and a better understanding of the disease biology in patients with a focus on worsening and acute heart failure and right heart failure.
