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One year of COVID-19: a look back at 2020 and where we are now

One year on from the emergence of SARS-COV-2 in Wuhan, China, this novel coronavirus continues to devastate the world. Since then, COVID-19 has reached every continent and touched all of our lives. In this article, we take the chance to assess the situation going into 2021 and look back on the first year of the pandemic.

Prestigious prize for Belgian breakthrough in brain research

Prof. Dr. Pierre Vanderhaeghen from VIB-KU Leuven has been awarded the Generet Prize for Rare Diseases for his research on human brain development. Vanderhaegen’s team have developed an astonishing model for studying rare neurological disorders by successfully integrating human neurons into a mouse brain. The prestigious prize, managed by the King Baudouin Foundation and presented to Vanderhaeghen by HRH Princess Astrid, includes EUR 1 million in funding for further studies.

The rapid evolution of Chinese biotech

The world is smaller today than it has ever been. With the COVID-19 pandemic, we have seen the advantages of a connected international pharma and biotech industry, which was able to rapidly mobilize to provide solutions for this global threat. The pandemic is not the only opportunity for cross-border collaborations, however. With an increasing focus on healthcare innovation, the rapid evolution of Chinese biotech is bringing benefits to companies and patients around the world.

Belgian biotechs partnering with China: deals of 2020

In 2019, a delegation of Belgian biotechs participated in an economic mission to China led by H.R.H. Princess Astrid. Co-organized with BioCentury’s annual China Healthcare Summit, the mission was a success: three of the participating companies have already signed deals with Chinese collaborators or investors. We spoke with the CEOs of these companies to find out what kind of deals they obtained, and to hear about their experiences of working with Chinese partners.

Long-term loyalty: A Belgian fund’s perspective on Chinese investors

Over the past few years, an increasing number of European biotechs have been signing deals with Chinese investors. The Chinese are increasingly interested in European, particularly Belgian, biotech. But it’s not just for money: strategic investments with potential deals seem to be at the forefront of these agreements. How do European venture capitalists feel about this trend? We spoke with Chris Buyse from Fund+ to find out.

A bridge from East to West: linking Chinese and European biotech

There are two main reasons why a European company might want to establish official links with a Chinese investor: funding, and access to the second largest healthcare market in the world. But don’t go rushing in blind!

Vascular dysfunction meets immune suppression

Tumors create complex microenvironments where they suppress the normal functioning of the immune system. Blood vessels and macrophages are an important part of this environment. A new VIB-KU Leuven startup called Montis Biosciences is working to enhance anti-tumor immunity by investigating interactions between perivascular macrophages and the tumor vasculature.

UAntwerp researchers find cause for mysterious nodding syndrome

For decades, researchers have been trying to uncover the cause of nodding syndrome, a mysterious and deadly form of epilepsy that only affects children on the African continent. In a collaboration between Belgian and African scientists, researchers from the University of Antwerp have now discovered the root cause of the disease. In a cascade of events, nodding syndrome is triggered by another disease called river blindness, which in turn is caused by parasitic worms spread by blackfly bites. As complicated as it sounds, this is great news for the children, as it means that nodding syndrome can easily be controlled by administering the anti-parasitic drug ivermectin and exterminating blackflies.

Countering COVID-19 with llama antibodies

In July 2020, VIB spin-off ExeVir Bio raised €23 million to advance a llama-derived antibody against COVID-19. The company is based on the work of VIB researchers, who showed that these nanobodies can protect against the coronavirus in lab animals. ExeVir has now announced it will start testing the drug in COVID-19 patients in the coming months. The scientists are aiming to have the therapy ready for widespread use by spring 2021.

Belgian stem cell company GST bought by German pharmaceutical giant

The German pharmaceutical giant Boehringer Ingelheim has acquired GST, a stem cell specialist based in Belgium. A part of the Anacura Group, GST’s main focus is in animal health, with its main product being a stem cell therapy for injured horses. Despite the acquisition, the company will remain in its labs near Ghent, keeping its research and production rooted in Flemish soil.

Drug combos: how much is 1 + 1?

Many of our current antiviral, antibacterial and anti-tumour medications are comprised of combinations of two or three active substances, selected on the basis that these combinations slow down emergence of drug resistance. We are currently witnessing a rapid expansion of disease indications for which exploratory drug combos are being tested, as well as of the rationales for combining drugs. In this article, we examine the drivers behind this trend and the inherent caveats and complexities of drug combo development.

Building bigger for Belgium’s maturing biotech scene

Biotech is booming in Belgium. To support the evolving needs of this world-class ecosystem, the Mariën family initiated and are realizing Obelisc: a new and additional Bio-accelerator in Ghent’s science park. The building will service the larger start-ups graduating from local bio-incubators as well as international companies looking to put down roots in Belgian soil.

Colorectal cancer discovery raises hope for microbiome treatment

A new mechanism causing colorectal cancer has been discovered by researchers from VIB and Ghent University. A specific protein was found to affect the integrity of the intestinal wall, allowing infiltrating bacteria to cause inflammation that drives cancer progression. Promisingly, the scientists also demonstrated that manipulating the immune system or microbiome can prevent this chain event, findings that may lead to new treatments for colorectal cancer.

Fundamental research leads to treatment breakthrough in rare genetic diseases

A basic research breakthrough is improving patient lives, as researchers realized their rare genetic condition could be treated by repurposing a common anti-diabetic medication. The treatment has already been tested on several patients and has been a huge success with clinical trials now being initiated around the world.

Belgian clinical trials for COVID-19

With COVID-19 cases soaring into the millions, and a vaccine still a long way off, patients are desperate for a treatment. In response, numerous clinical trials have been initiated around the world. The majority of these trials are examining existing drugs to see if they can be repurposed to treat COVID-19. We spoke with Prof. Bart Lambrecht, pulmonologist at Ghent University Hospital (UZ Gent), about some of the clinical trials taking place here in Belgium.