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From successful conception to a healthy family – Belgian research raises the bar for IVF

Belgium is one of the top countries in the world for in vitro fertilization (IVF). Despite the high cumulative success rates of these interventions, disproportionally little attention has been given to the health of both mother and child during and after pregnancy. With the HEART (High risk for pre-Eclampsia after Assisted Reproductive Technology) project, Belgian researchers strive to understand why some women have an increased risk for pre-eclampsia after IVF and whether biomarkers can be identified to estimate these risks early in pregnancy or even before conception. They aim to raise the standard from successful conception to improved child and maternal health.

This vagina-on-chip model holds the potential to advance yeast infection research

While a vast majority of women experience vaginal yeast infections, research has fallen short in providing an effective treatment approach. However, hope has emerged recently with the development of new model systems that allow exploration of the complex vaginal environment. Organ-on-chip models enable researchers to examine the interactions between human cells and microbes in a more accurate manner, offering the potential for the development of new therapies.

Bridging the immunity gap: improving animal welfare without antibiotics

Antibiotic resistance is a major concern for humans and animals. Increasing pressure to move away from antibiotics has created space for new solutions for disease management. Animab’s oral monoclonal antibody platform is a promising alternative, effectively guarding against infection during a vulnerable period in an animal’s development.

Optimizing the patient care pathway through data-driven insights

The patient’s journey in a healthcare setting is influenced by factors beyond the mere medical aspects of the case. Local variations in care procedures among hospitals and caregivers enable benchmarking and adaptation of practices to optimize outcomes. For effective process modeling, it’s essential to collect data and extract insights. To optimize this process efficiently, collaborative efforts should explore alternative data sources and implement novel tools.

Nutritional labels “in the wild”: how they affect your snack choice

Barely any people stick to a three-meals-a-day plan. Snacking is part of our culture and can even contribute to a healthy diet when choosing the right snacks. But your appetite doesn’t always agree about what’s the “right” snack. Your hands automatically reach for those candy bars, instead of a handful of nuts. Therefore, we investigated whether two different nutritional labels – calorie labels and the Nutri-Score – can nudge you in the right direction.

Beyond gluten-free: a hopeful future for those who suffer from Celiac disease

Gluten-free dietary products contain more sugar and fats but fewer nutrients and are generally more expensive. A gluten-free diet can even lead to social isolation and stigmatization. Scientists are thus looking for a way that allows people with celiac gluten intolerance disease to enjoy the benefits of gluten in a safe manner.

Looking forward: Azalea Vision’s smart lens is a game-changer for ocular disorders

In December 2023, Azalea Vision announced the first test of their smart contact lens on a real person. This demonstration showcased the first functional prototype of their smart lens, known as the ALMA lens, which was developed by the company to address ocular disorders characterized by the inability to effectively filter light.

Smart cities as living laboratories: a data-driven strategy for creating a sustainable future

Similar to the growing use of large-scale scientific data to guide laboratory research, urban data presents significant potential for informed decision-making in city governance. Extensive data on waste collection, traffic, pollution, and various other facets of city management can be collected and analyzed to help policymakers identify challenges and develop prediction-based solutions. Thomas Van Oppens, Deputy Mayor of Leuven, underscores the importance of local collaboration in establishing such a data-driven growth model for city governance.

Belgian breakthrough in endometriosis research captures investors’ attention

Even though endometriosis impacts millions of women globally, the condition remains poorly understood and researched, leading to delayed diagnosis and lack of effective treatment. Encouragingly, there are promising recent developments in the field coming from Belgium. Professor Hugo Vankelecom’s research group at KU Leuven uses advanced cellular models, known as organoids, to delve into the disease and expedite the drug discovery process. The Danish BioInnovation Institute now offers the team an incubation program to pave the way towards industrial success.

Using real-world data for post-market surveillance of drug safety

After a therapeutic drug hits the market, it is crucial to continuously gather, analyze, and report data regarding its safety and potential side effects, a practice known as pharmacovigilance. Unlike clinical trials, this involves real-world data (RWD), presenting unique challenges in terms of both quality and quantity. The Belgian BELpREG project seeks to employ RWD for monitoring drug utilization during pregnancy and investigating potential safety implications for both maternal and child health. This initiative holds great promise, although it faces substantial hurdles on its path to success.

Muna Therapeutics: hopeful solutions for memory loss

Muna Therapeutics is developing transformative therapies for neurodegenerative diseases. These drugs aim to preserve cognition and enhance the brain’s resilience in diseases like Alzheimer’s and Parkinson’s, providing much-needed hope for millions of patients and their loved ones.

Intelligent dentistry: AI is making surgeries safer

The AIPLANT project aims to reduce complications from dental implant surgery using AI-based preoperative planning. The project is a collaboration between the Centre for Dentomaxillofacial Imaging at UZ Leuven, AI startup Relu, and Xentro Dental. 

Health data standardization: What FHIR can do for you!

Patient data is a treasure trove of information, vital to tailoring individual care pathways and generating profound insights to enhance healthcare more broadly. However, achieving interoperability among the diverse systems employed by various healthcare providers remains a critical challenge. Data standards like FHIR can help to streamline the secure exchange and seamless integration of healthcare data across these different systems. This article will take you through the FHIR framework and how it could be used by your organization.

Pharmaceutical market access: how real-world data fuel better health beyond clinical trials

Studies of a drug's effectiveness and safety don’t end with clinical trials – they extend beyond market access when the true value of a drug is demonstrated in a real-world setting. Based on this information, factors such as availability, pricing, and reimbursement are adjusted. To study the actual worth of a treatment, we require real-world data (RWD) from a large and diverse patient population. By actively sharing this information with stakeholders, we can fuel further research and innovation, and even help to inform decision-making on a population level. But in order to unlock the full potential of our patient data, all members of the ecosystem have to work together.

Hearts in space: a Belgian story of successful collaboration

AstroCardia has developed a heart-on-a-chip to study cardiovascular aging… in space! Trials will begin in 2025 aboard the International Space Station (ISS). The MEDVIA project was made possible thanks to the combined expertise of the five Belgian partners: Space Applications Services, the Belgian Nuclear Research Center (SCK CEN), QbD Group, BIO INX, and Antleron.