Subscribe
Subscribe

Biomedical/pharma

Biomedical/pharma, Immunology, Neurology

Coave Therapeutics: redecorating viral vectors for improved gene therapies

Coave Therapeutics is a French biotech developing gene therapies for neurodegenerative and ocular diseases. The company has developed a technology platform that can be used to redecorate the outer surface of viruses, creating gene therapy vectors that are better at accurately delivering healthy genes to the right target cells, including neurons in the deep brain tissue. By combining this vector technology with transgenes restoring natural cell cleaning pathways, the company has created a pipeline of therapies for both genetically and non-genetically defined neurodegenerative diseases, such as Parkinson’s Disease, Multiple System Atrophy (MSA), and Amyotrophic Lateral Sclerosis (ALS).

Great at small things: BCCM stores microorganisms, plasmids, hybridomas, and more!

BCCM is a Belgian non-profit consortium of seven biological resource centers preserving and distributing microbial and genetic resources, offering storage and scientific services for both academia and industry. These world-class collections are exceptional in terms of the number and variety of specimens and excellent quality control. BCCM’s confidential deposit services are a great way for companies to store genetic material and microorganisms for safety or patent purposes, including hybridomas and other cell lines.

From multiple pills per day to one treatment per month: progress in HIV medication made possible by pharma collaborations

Unprecedented collaborations between different pharmaceutical companies have resulted in extraordinary progress for HIV patients over the past four decades. From the first ever treatments, to single pills and now even long-acting injections, treatment options have come a long way. In this interview, Dr. Theresa Pattery (Head of Disease Management Programs at Janssen Pharmaceutica) tells us of this long journey and talks about the role of drones and phones in the world-wide fight against HIV.

Data science in early drug discovery – getting it right from the start

The application of data science in the early stages of drug development is not new – progress in algorithms and computing power has been ongoing for years. We have reached the point where we have to reflect on the road travelled and look forward to upcoming opportunities and challenges. To further pave the way and reach the top in health data science, stakeholders will have to find each other and work together. Once everyone is on board, data science knows no bounds!

Cancer vaccines: not only treating tumors, but preventing them too

The COVID-19 pandemic has brought vaccines back into the drug development spotlight, and mRNA vaccines are stealing the show with sales of USD 54.4 billion in 2021 alone. Few know that the developers of the mRNA COVID-19 vaccines actually drew upon years of experience attempting to develop cancer vaccines. This approach goes back several decades, and although the field has to date seen limited success, it has nevertheless witnessed a renewed interests in recent years. We examine the latest trends in cancer vaccine development, and where the opportunities lie for the future of the industry.

New personalized cancer vaccine in the making thanks to unique Belgian collaboration

The young Belgian start-up Persomed is unique – it was founded in 2020 by four partners each with relevant expertise in the personalized immunotherapy field: myNEO, QbD Group, Antleron, and the VUB. Together, the multidisciplinary strength and expertise has resulted in the development of Persomed’s cutting-edge technology platform for personalized cancer treatments. The organization is now at crucial point, raising funds to initiate a clinical trial phase I in a first, urgent-medical-need indication: metastatic colorectal cancer.

Marfan patients team up with researchers to catch their silent killer

The world’s undiagnosed Marfan patients often go through life unaware of the hidden killer lurking in their DNA – a gene variant which may lead to sudden death at any moment via an aortic dissection. Currently, there is no therapy available to counteract this disastrous aortic event, so patient awareness of their condition is key to prevention. To learn more about Marfan syndrome and improve diagnosis, our project needs patients to enroll online in our research cohort. In this way, patients themselves can help us contribute to new therapies and avert sudden deaths.

Rejuvenate Biomed’s newly appointed Clinical Advisory Board endorses Clinical Phase 2b strategy in sarcopenia

Is Belgium becoming a hub for gene therapy?

Intressa Vascular secures EUR 18 million in financing to support the development of its multilayer Allay™ Aortic Stent for the treatment of aortic dissection

Intressa Vascular is using its proprietary stent braiding technology to develop an innovative multilayer stent for the treatment of aortic dissection, a life-threatening cardiovascular condition affecting worldwide 300,000 patients annually. The company has secured EUR 18 million in financing with the support of new investors and the Walloon Region. Funds are aimed at clinical studies and product registration purposes.

Gene therapy challenges and the solutions in sight

Dr. Federico Mingozzi is the CSO of Spark Therapeutics, the company behind Luxturna – the world’s first FDA-approved gene therapy for a genetic disease. Though we like to focus on success stories like Luxturna, the reality is that gene therapy is a new modality, and the field is still developing. We spoke to Dr. Mingozzi about some of the technical challenges currently hampering progress in gene therapy, and how people are working together to overcome these hurdles.

Picking up early signals: SPINOVIT to prevent cardiovascular diseases with new monitoring method

Preventing cardiovascular diseases before the first symptoms arise? That’s the ambition of SPINOVIT – a Louvain-La-Neuve company using a new biomarker and innovative technology to achieve its goal. A large clinical trial should be finished in 2023, after which the young company’s product will be launched on the market. In the long term, SPINOVIT’s solution could become part of people’s annual blood check-ups.

V-Bio Ventures leads Sibylla Biotech’s EUR 23 million Series A to advance a novel therapeutic approach for undruggable diseases

NeuVasQ Appoints Former UCB Ventures VP and Partner Emmanuel Lacroix as Chief Executive Officer and Expands Its Board of Directors

From pattern to patient: microbiome research needs to bridge the gap to the clinic

The microbiome has been a trending scientific topic in recent years. Researchers have uncovered correlations between the human microbiome and a wide range of diseases and health states, ranging from digestive issues to mental wellbeing. But no matter how fascinating these academic findings may be, translating them into concrete clinical applications remains a challenge. How can we enable more efficient clinical valorization of microbiome insights, and pave the way from pattern to patient?