Amy LeBlanc

In mid-2021, research institute VIB will open its brand-new agbiotech incubator. The new complex will provide entrepreneurs with access to high-tech facilities to work on sustainable agricultural innovations, like solutions to make plants more resistant to drought. The incubator will be housed in the former CropDesign site of multinational BASF in Nevele, Belgium.
The world is smaller today than it has ever been. With the COVID-19 pandemic, we have seen the advantages of a connected international pharma and biotech industry, which was able to rapidly mobilize to provide solutions for this global threat. The pandemic is not the only opportunity for cross-border collaborations, however. With an increasing focus on healthcare innovation, the rapid evolution of Chinese biotech is bringing benefits to companies and patients around the world.
In 2019, a delegation of Belgian biotechs participated in an economic mission to China led by H.R.H. Princess Astrid. Co-organized with BioCentury’s annual China Healthcare Summit, the mission was a success: three of the participating companies have already signed deals with Chinese collaborators or investors. We spoke with the CEOs of these companies to find out what kind of deals they obtained, and to hear about their experiences of working with Chinese partners.
Over the past few years, an increasing number of European biotechs have been signing deals with Chinese investors. The Chinese are increasingly interested in European, particularly Belgian, biotech. But it’s not just for money: strategic investments with potential deals seem to be at the forefront of these agreements. How do European venture capitalists feel about this trend? We spoke with Chris Buyse from Fund+ to find out.
There are two main reasons why a European company might want to establish official links with a Chinese investor: funding, and access to the second largest healthcare market in the world. But don’t go rushing in blind!
After several years of nominations, Emmanuelle Charpentier and Jennifer Doudna have finally been awarded the 2020 Nobel Prize in Chemistry for their development of CRISPR/Cas genetic editing. These ‘genetic scissors’ can be used to can change the DNA of animals, plants and microorganisms with unprecedented precision. CRISPR technology has already had a revolutionary impact on the life sciences, but the technique and the Nobel prize itself aren’t without controversy.
Developing new therapies is sometimes not enough: for retinal indications, accurate delivery is key to making a drug work. Lowering the patient burden by minimizing injections is also an important factor to consider. Oxular, an Oxford-based biotech and V-Bio Ventures portfolio company, has developed a technology platform to address the unmet need for less frequent dosing and better drug delivery in retinal diseases.
Tumors create complex microenvironments where they suppress the normal functioning of the immune system. Blood vessels and macrophages are an important part of this environment. A new VIB-KU Leuven startup called Montis Biosciences is working to enhance anti-tumor immunity by investigating interactions between perivascular macrophages and the tumor vasculature.
In an effort to raise awareness for alternatives to animal models, BioVox is helping to promote an Organ-on-Chip initiative by Dutch startup Bi/ond. The initiative aims to increase awareness and adoption of Organ-on-Chip technology, to improve in vitro research models and reduce animal testing.
For the third year in a row, Belgium has been ranked the number one country in Europe for biotech! Belgium is consistently included in the top five countries on a number of measures. But when it comes to the total market value of all public biotech companies in Europe, Belgium really takes the cake with a huge 24% slice. Furthermore, despite pressure from the pandemic, the value of Belgian biotech companies has increased by no less than 56% in the past year to €42 billion, putting 2020 on course to be a record-breaking year in a positive way. The great news was presented by KBC Securities at the virtual State of the Union organized by flanders.bio and VIB for this year’s Knowledge for Growth.
Every year, the Dr. Paul Janssen Award for Biomedical Research is granted to a scientist who embodies the eponymous man’s dedication to his patients and unfailing curiosity and passion for scientific progress. The 2020 winner of this prestigious award is Dr. Lewis Cantley, who discovered the family of PI3K enzymes, thereby increasing our understanding of a wide range of diseases including cancer and diabetes. Nearly 30 years on from this seminal discovery, Dr. Cantley’s research has resulted in more precise cancer therapies that have saved patient lives, making him a true champion of science.
For decades, researchers have been trying to uncover the cause of nodding syndrome, a mysterious and deadly form of epilepsy that only affects children on the African continent. In a collaboration between Belgian and African scientists, researchers from the University of Antwerp have now discovered the root cause of the disease. In a cascade of events, nodding syndrome is triggered by another disease called river blindness, which in turn is caused by parasitic worms spread by blackfly bites. As complicated as it sounds, this is great news for the children, as it means that nodding syndrome can easily be controlled by administering the anti-parasitic drug ivermectin and exterminating blackflies.
In July 2020, VIB spin-off ExeVir Bio raised €23 million to advance a llama-derived antibody against COVID-19. The company is based on the work of VIB researchers, who showed that these nanobodies can protect against the coronavirus in lab animals. ExeVir has now announced it will start testing the drug in COVID-19 patients in the coming months. The scientists are aiming to have the therapy ready for widespread use by spring 2021.
In August 2020, V-Bio Ventures announced their investment in Biodol Therapeutics, a French start-up looking to make a difference to people suffering from chronic pain. The company is developing a drug to treat neuropathic pain by addressing the interplay between nerves and the immune system. In a billion-dollar market dominated by ineffective and dangerous painkillers, their unique approach could reduce the suffering of millions.
The German pharmaceutical giant Boehringer Ingelheim has acquired GST, a stem cell specialist based in Belgium. A part of the Anacura Group, GST’s main focus is in animal health, with its main product being a stem cell therapy for injured horses. Despite the acquisition, the company will remain in its labs near Ghent, keeping its research and production rooted in Flemish soil.