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Data science – taking clinical drug development to the next level

Clinical drug development is a challenging endeavor, but help is at hand! From trial site selection, to patient recruitment, to endpoint characterization – data science integration can help to overcome bottlenecks and improve efficiency in clinical development by generating unique insights to help guide study design and operations. For this strategy to be used to its full potential in Belgium, local partners should optimize data governance and quality, and improve collaboration. This would help the country maintain its status as a leading location for clinical trials.

Brewing up a new business: AB InBev surprises with ambitions for animal-free proteins

Belgian-American AB InBev, the world's largest brewer, has set up a separate R&D division called BioBrew to develop animal-free proteins using precision fermentation. Quite a number of companies are already focused on producing alternative proteins, which don’t cause harm to animals and are more sustainable, but they generally lack the capacity to produce them on a commercial level. This is one of the things that sets BioBrew apart, thanks to AB InBev’s knowhow of using yeast fermentation on a large scale to make beer.

Energizing the transition: ACROBAT consortium devises smart and sustainable ways to recycle LFP batteries

Batteries are a crucial component of the energy transition away from fossil fuels, but the technology currently faces issues with sustainable recycling methods, which are vital for recuperating the rare raw materials inside the power cells. The European ACROBAT consortium, led by Flemish research center VITO, is tackling this issue specifically for LFP batteries – a type of lithium-ion batteries that are steadily growing in importance, including for electric cars.

The chaos of choice: how do people pick their food products?

Every family needs groceries, and most people regularly venture to the supermarket to gather supplies. If researchers can help shoppers make healthier choices, we can improve the obesity problem in a simple yet effective way. But until recently, nobody really understood what motivated people to choose certain products – we knew what they bought, but not why. We’ve therefore investigated shoppers’ choice strategies, hoping to use this information to help people choose healthier.

Stew before you chew – why the way you cook pulses makes a difference to your nutrition

Do you look at the composition or caloric content of foods to make healthy choices? In healthy foods, not only the nutritional composition is important, but also how those nutrients are digested. Our research on pulses – such as beans, chickpeas, and lentils – showed that the way in which pulses are prepared determines how nutrients will be released in our bodies during digestion. To understand this, we need to look at pulses under the microscope.

New personalized cancer vaccine in the making thanks to unique Belgian collaboration

The young Belgian start-up Persomed is unique – it was founded in 2020 by four partners each with relevant expertise in the personalized immunotherapy field: myNEO, QbD Group, Antleron, and the VUB. Together, the multidisciplinary strength and expertise has resulted in the development of Persomed’s cutting-edge technology platform for personalized cancer treatments. The organization is now at crucial point, raising funds to initiate a clinical trial phase I in a first, urgent-medical-need indication: metastatic colorectal cancer.

Marfan patients team up with researchers to catch their silent killer

The world’s undiagnosed Marfan patients often go through life unaware of the hidden killer lurking in their DNA – a gene variant which may lead to sudden death at any moment via an aortic dissection. Currently, there is no therapy available to counteract this disastrous aortic event, so patient awareness of their condition is key to prevention. To learn more about Marfan syndrome and improve diagnosis, our project needs patients to enroll online in our research cohort. In this way, patients can themselves help us contribute to new therapies and averting sudden deaths.

Picking up early signals: SPINOVIT to prevent cardiovascular diseases with new monitoring method

Preventing cardiovascular diseases before the first symptoms arise? That’s the ambition of SPINOVIT – a Louvain-La-Neuve company using a new biomarker and innovative technology to achieve its goal. A large clinical trial should be finished in 2023, after which the young company’s product will be launched on the market. In the long term, SPINOVIT’s solution could become part of people’s annual blood check-ups.

From pattern to patient: microbiome research needs to bridge the gap to the clinic

The microbiome has been a trending scientific topic in recent years. Researchers have uncovered correlations between the human microbiome and a wide range of diseases and health states, ranging from digestive issues to mental wellbeing. But no matter how fascinating these academic findings may be, translating them into concrete clinical applications remains a challenge. How can we enable more efficient clinical valorization of microbiome insights, and pave the way from pattern to patient?

Bacterial biofilms: cooperative bugs cling to food surfaces even after cleaning

Current cleaning and disinfection practices in food industries are insufficient to destroy unwanted bacteria lurking on surfaces, according to recent Belgian research. Cooperation between diverse types of bacteria makes them stronger and more resilient, causing huge damage in terms of food spoilage, recalls, and health issues. Understanding the development of these microbial communities and their underlying cooperation is vital for assuring food safety, and may lead to developing better forms of biocontrol.

Modern alchemy: turning microalgae into ‘green gold’

Much has been said about the huge economic potential of algae, but this ‘green gold’ has yet to meet expectations. The European project IDEA – led by Belgian research center VITO – is examining the economic benefits of microalgae and developing strategies to overcome remaining challenges. Interim results show that algae can very well be grown in the climate of Northwestern Europe and can be used to efficiently produce products such as healthy biscuits, animal feed and cosmetic applications.

Beethoven and bone conduction: modern hearing solutions based on old tricks

The famous composer Ludwig Von Beethoven lost his hearing at a young age. To keep composing, he actively looked for a way to compensate for his hearing loss. He managed to find a solution by making clever use of the bone conduction of sound. To this day, bone-anchored hearing aids help people stay in tune with the auditory world around them. Researchers at pioneering company Cochlear Limited in Belgium are actively working on the future of this technology.

Obesity weighs heavy on healthcare and human lives

Being overweight is not only bad for one’s health – it also costs society a lot of money. Every year, the Belgian government loses at least 4.5 billion euros due to the direct and indirect costs linked to excessive weight and obesity. As with COVID-19, this issue needs to be tackled as a public health concern: the responsibility of both individuals and policymakers.

Indigo develops device to make light work of diabetes management

Ghent-based Indigo aims to make a huge difference to the quality of life of people with diabetes. The company is developing a device to render the monitoring of blood sugar levels painless and invisible, a major improvement compared to the tools available today. The innovative technology is based on spectroscopy – using light to measure glucose levels through the skin.

IBA and SCK CEN partnership to produce rare radioisotope for cancer treatments

The radioisotope Actinium-225 shows clear promise in the battle against cancer, but to fulfil its potential we will need to enable large-scale production of the rare substance. A collaboration between IBA – the world’s leading company in particle accelerator technology – and the Belgian Nuclear Research Center (SCK CEN) now makes this crucial step possible. The partners are constructing a production plant on the SCK CEN site in the Flemish city of Mol.