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An insightful solution to eye injections

Developing new therapies is sometimes not enough: for retinal indications, accurate delivery is key to making a drug work. Lowering the patient burden by minimizing injections is also an important factor to consider. Oxular, an Oxford-based biotech and V-Bio Ventures portfolio company, has developed a technology platform to address the unmet need for less frequent dosing and better drug delivery in retinal diseases.

New initiative to promote transition to Organ-on-Chip technology

In an effort to raise awareness for alternatives to animal models, BioVox is helping to promote an Organ-on-Chip initiative by Dutch startup Bi/ond. The initiative aims to increase awareness and adoption of Organ-on-Chip technology, to improve in vitro research models and reduce animal testing.

Belgium: the number one biotech country in Europe!

For the third year in a row, Belgium has been ranked the number one country in Europe for biotech! Belgium is consistently included in the top five countries on a number of measures. But when it comes to the total market value of all public biotech companies in Europe, Belgium really takes the cake with a huge 24% slice. Furthermore, despite pressure from the pandemic, the value of Belgian biotech companies has increased by no less than 56% in the past year to €42 billion, putting 2020 on course to be a record-breaking year in a positive way. The great news was presented by KBC Securities at the virtual State of the Union organized by flanders.bio and VIB for this year’s Knowledge for Growth.

Get to know Lewis Cantley: winner of the 2020 Dr. Paul Janssen Award

Every year, the Dr. Paul Janssen Award for Biomedical Research is granted to a scientist who embodies the eponymous man’s dedication to his patients and unfailing curiosity and passion for scientific progress. The 2020 winner of this prestigious award is Dr. Lewis Cantley, who discovered the family of PI3K enzymes, thereby increasing our understanding of a wide range of diseases including cancer and diabetes. Nearly 30 years on from this seminal discovery, Dr. Cantley’s research has resulted in more precise cancer therapies that have saved patient lives, making him a true champion of science.

Can Darwin’s theory explain why we get sick?

While physicians care for their individual patients and are interested in the factors contributing to the individual’s condition, evolutionary biologists investigate the cause of the biological phenomenon, trying to understand for example why a certain disease has developed in a particular species such as our own Homo sapiens. By combining the view of physicians with the view of evolutionary biologists, the field of evolutionary medicine has the potential to improve our understanding of certain diseases and how to prevent them.

A novel approach to neurology could bring relief to people in pain

In August 2020, V-Bio Ventures announced their investment in Biodol Therapeutics, a French start-up looking to make a difference to people suffering from chronic pain. The company is developing a drug to treat neuropathic pain by addressing the interplay between nerves and the immune system. In a billion-dollar market dominated by ineffective and dangerous painkillers, their unique approach could reduce the suffering of millions.

VIB: the driving force behind a booming biotech ecosystem

Since VIB was established, the world class research institute has been led by a duo of managing directors. As Johan Cardoen recently stepped down for health reasons, Jérôme Van Biervliet has been chosen for the position alongside Jo Bury. We sat down with both Jérôme Van Biervliet and Jo Bury to hear their thoughts on VIB’s vital role in the ever-evolving Belgian biotech ecosystem.

The opioid epidemic: solutions to a painful problem

Opioid misuse is a public health crisis that has resulted in debilitation, deaths, and significant social and economic impact. The epidemic has been fueled by widespread abuse of prescription opioids and a dramatic increase in the availability of illicit opioids such as heroin. In this article, we examine some steps to overcoming this issue and improving the way we treat pain.

To prevent another pandemic, we need to improve our relationship with animals

How changing diets gave rise to the world’s deadliest diseases

In a recent article, we discussed how the most prescribed drugs are usually indicated for common noncommunicable diseases. These include chronic conditions like diabetes, heart disease, GERD and mental health issues. Regarding treatment innovation, these prevalent diseases are often underserved when compared to less common, but more profitable, orphan diseases. In this article, we look at some of the underlying factors causing these noncommunicable diseases and what could be done to prevent them.

Talking T cells with David Masopust

Immunology is a complex but vitally important branch of the life sciences. Earlier this year, we attended a Keystone Symposia conference on T cell immunology as media partners. There, we got to speak with Prof. David Masopust, the man who discovered resident memory T cells. His seminal breakthrough opened up a new branch of T cell biology and catapulted the field forwards. Masopust shares his thoughts on the enormous untapped potential of T cells in new treatments and vaccines.

Cell therapies: opportunities and challenges

Recent activities in the cell therapy field have prompted many investment funds to pour fresh and increasing capital into this space. In this review, we share some observations and highlight a few of the questions that arise when new modalities cross the bridge from bench to bed.

TheSocialMedwork: equal access to medicines for everyone, everywhere

We recently sat down with Sjaak Vink, the visionary entrepreneur behind TheSocialMedwork. This enterprise gives patients all over the world access to medication that has not yet been approved in their home countries. We spoke with Vink about his personal motivations for founding TheSocialMedwork and his dream for universal basic healthcare.

Potential impact of the corona crisis on the life sciences industry

Over the past few months, every news headline has focused on COVID-19. The industry is accelerating its own in-house research to match the pace of the pandemic. The business development market is wide open, as large and mid-sized pharma companies are interested in partnering with early stage initiatives to advance investigational COVID-19 programs (in addition to pursuing their own in-house activities).

Augustine Therapeutics: bridging the valley of death with VIB Discovery Sciences

Augustine Therapeutics is one of VIB’s latest spinoffs, developing a first-in-class drug for Charcot-Marie-Tooth disease. The company recently announced a seed-funding round of €4.2 million, led by V-Bio Ventures. We spoke to several of the key persons in Augustine about how the startup is tackling the “Valley of Death”: the no-man’s-land between academia and industry where many potential therapies often fail.